Starvation

While a vampire is, for the most part, is invincible, immortal, and impervious to almost every form of bodily harm they do possess a weakness: the heart. Damaging the heart of a vampire beyond repair will undoubtedly lead to death. Because the heart pumps donor's blood through a vampire's veins, without it, no matter how many donors are preyed upon, the body cannot hope to survive as the blood simply 'leaks' away. This leads to starvation, an extremely painful and agonizing experience for a creature of darkness. A quick death is often preferred to the slow miserable fading away of a vampire without hope of ever healing its wounds.

Starvation, through the use of a Shiv to pierce the heart is the favoured method of hunters for destroying their targets, as they are the only means of ensuring that a targeted vampire dies of their wounds.